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Poisoning & Overdose | Part Two | Cholinergics | Anti Cholinergics

Cholinergics: stimulate the parasympathetic nervous system, block the breakdown of acetylcholine. Pesticides like organophosphates and nerve gas agents like sarin, or soman.

Severe symptoms are called: SLUDGEM
Salivation
Lacrimation
Urination
Defecation
Gi cramping
Emesis
Miosis

Bradycardia
Wheezing
Myosis
Coma
Convulsions
Management: Own safety! HazMat only. Atropine, Pralidoxime (2-pam chloride), Diazepam, Activated Charcoal if oral ingestion

Anticholinergics: block the parasympathetic nervous system, also called vagolytic agents. Atropine, ipratropium, antihistamines, antispasmodics, tricyclic antidepressants

Severe symptoms will be hot, red, dry and mad
Tachycardia, tachypnea
Temporary psychosis

Management: Maintain ABCs. Counter-drugs are rarely given, they are more dangerous than the anticholenergics themselves. Treat the symptoms. Activated charcoal may help.

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